Urotensin II receptor

C-terminal domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (7 - 13 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. [1] Qi J. S. Minor L. K. Smith C. Hu B. Yang J. Andrade-Gordon P. and Damiano B. Characterization of functional urotensin II receptors in human skeletal muscle myoblasts: comparison with angiotensin II receptors[2] Suzuki S. Wenyi Z. Hirai M. Hinokio Y. Suzuki C. Yamada T. Yoshizumi S. Suzuki M. Tanizawa Y. Matsutani A. and Oka Y. Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese[3] Bousette N. Patel L. Douglas S. A. Ohlstein E. H. and Giaid A. et al. Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta[4] Birker-Robaczewska M. Boukhadra C. Studer R. Mueller C. Binkert C. and Nayler O. The expression of urotensin II receptor (U2R) is up-regulated by interferon-gamma[5] Maguire J. J. Kuc R. E. and Davenport A. P. et al. Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1[6] Ames R. S. Sarau H. M. Chambers J. K. Willette R. N. Aiyar N. V. Romanic A. M. Louden C. S. Foley J. J. Sauermelch C. F. Coatney R. W. et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. [7] Sugo T. Murakami Y. Shimomura Y. Harada M. Abe M. Ishibashi Y. Kitada C. Miyajima N. Suzuki N. Mori M. et al. Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain.