C-C chemokine receptor type 7

GWB-7E08C2

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Expressed in various lymphoid tissues and activated B- and T-lymphocytes strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV) and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. [1] Fritsch R. D. Shen X. Sims G. P. Hathcock K. S. Hodes R. J. and Lipsky P. E. Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27[2] Kim J. W. Ferris R. L. and Whiteside T. L. et al. Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosis[3] Parmiani G. Castelli C. and Rivoltini L. et al. Chemokine receptor 7 a new player in regulating apoptosis of CD8+ T cells in cancer patients[4] Cabioglu N. Yazici M. S. Arun B. Broglio K. R. Hortobagyi G. N. Price J. E. and Sahin A. CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer[5] Minetti C. Gattorno M. Repetto S. Gregorio A. Pedemonte M. Assereto S. Zara F. Bruno C. and Martini A. Chemokine receptor CCR7 is expressed in muscle fibers in juvenile dermatomyositis[6] Birkenbach M. P. Josefsen K. Yalamanchili R. R. Lenoir G. M. Kieff E. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. [7] Schweickart V. L. Raport C. J. Godiska R. Byers M. G. Eddy R. L. Jr. Shows T. B. Gray P. W. Cloning of human and mouse EBI1 a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21. 2. [8] Kopatz S. A. Aronstam R. S. Sharma S. V. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [9] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences.