Nuclear receptor 0B2

Ligand-binding domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (13 ug/ml) (Optimal dilution to be determined by the researcher)

Interacts with RARA RXRA THRB NR5A1 NR5A2 NR1I3 PPARA and PPARG. May also interact with HNF4A (By similarity).

Liver. Low levels of expression were detected in heart and pancreas.

Belongs to the nuclear hormone receptor family. NR0 subfamily. Summary: The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family a group of transcription factors regulated by small hydrophobic hormones a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors inhibiting their ligand-dependent transcriptional activation. In addition interaction with estrogen receptors has been demonstrated leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [1] Datta S. Wang L. Moore D. D. and Osborne T. F. et al. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake[2] Eloranta J. J. Jung D. and Kullak-Ublick G. A. et al. The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha and suppressed by bile acids via a small heterodimer partner-dependent mechanism[3] Boulias K. Katrakili N. Bamberg K. Underhill P. Greenfield A. and Talianidis I. Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP[4] Ortlund E. A. Lee Y. Solomon I. H. Hager J. M. Safi R. Choi Y. Guan Z. Tripathy A. Raetz C. R. McDonnell D. P. Moore D. D. and et al. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP[5] Kim J. Y. Kim H. J. Kim K. T. Park Y. Y. Seong H. A. Park K. C. Lee I. K. Ha H. Shong M. Park S. C. and Choi H. S. Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding[6] Seol W. Choi H. -S. Moore D. D. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. [7] Lee H. -K. Lee Y. -K. Park S. -H. Kim Y. -S. Park S. H. Lee J. W. Kwon H. -B. Soh J. Moore D. D. Choi H. -S. et al. Structure and expression of the orphan nuclear receptor SHP gene. [8] Nishigori H. Tomura H. Tonooka N. Kanamori M. Yamada S. Sho K. Inoue I. Kikuchi N. Onigata K. Kojima I. et al. Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. [9] Gregory S. G. Barlow K. F. McLay K. E. Kaul R. Swarbreck D. Dunham A. Scott C. E. Howe K. L. Woodfine K. Spencer C. C. A. et al. The DNA sequence and biological annotation of human chromosome 1. [10] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences.