Orphan nuclear receptor NR6A1

Ligand-binding domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (4 ug/ml) (Optimal dilution to be determined by the researcher)

Interacts with RXRIP110 (By similarity).

Testis specific.

Contains 1 nuclear receptor DNA-binding domain. Summary: This protein is an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA but in vivo targets have not been identified. The gene expresses three alternatively spliced transcript variants. [1] Yan Z. Kim Y. S. and Jetten A. M. et al. RAP80 a novel nuclear protein that interacts with the retinoid-related testis-associated receptor[2] Mehta D. V. Kim Y. S. Dixon D. and Jetten A. M. et al. Characterization of the expression of the retinoid-related testis-associated receptor (RTR) in trophoblasts[3] Susens U. and Borgmeyer U. et al. Genomic structure of the gene for mouse germ-cell nuclear factor (GCNF). II. Comparison with the genomic structure of the human GCNF gene[4] Schmitz T. P. Susens U. and Borgmeyer U. et al. DNA binding protein interaction and differential expression of the human germ cell nuclear factor[5] Greschik H. Wurtz J. M. Hublitz P. Kohler F. Moras D. and Schule R. Characterization of the DNA-binding and dimerization properties of the nuclear orphan receptor germ cell nuclear factor[6] Schneider-Hirsch S. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases. [7] Kapelle M. Kraetzschmar J. Husemann M. Schleuning W. -D. cDNA cloning of two closely related forms of human germ cell nuclear factor (GCNF). [8] Lei W. Hirose T. Zhang L. -X. Adachi H. Spinella M. J. Dmitrovsky E. Jetten A. M. Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation. [9] Susens U. Borgmeyer U. Characterization of the human germ cell nuclear factor gene. [10] Agoulnik I. Y. Cho Y. Niederberger C. Kieback D. G. Cooney A. J. Cloning expression analysis and chromosomal localization of the human nuclear receptor gene GCNF.