C-C chemokine receptor type 10

2nd extracellular domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (11 - 17 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: Chemokines are a group of small (approximately 8 to 14 kD) mostly basic structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane G protein-coupled receptors. Chemokines also play fundamental roles in the development homeostasis and function of the immune system and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies CXC and CC based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al. 2002). [supplied by OMIM]. [1] Rodrigues-Lisoni F. C. Mehet D. K. Peitl P. Jr. John C. D. da Silva Junior W. A. Tajara E. Buckingham J. C. and Solito E. In vitro and in vivo studies on CCR10 regulation by Annexin A1[2] Notohamiprodjo M. Segerer S. Huss R. Hildebrandt B. Soler D. Djafarzadeh R. Buck W. Nelson P. J. and von Luettichau I. CCR10 is expressed in cutaneous T-cell lymphoma[3] Lehner B. Semple J. I. Brown S. E. Counsell D. Campbell R. D. and Sanderson C. M. Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region[4] Homey B. Alenius H. Muller A. Soto H. Bowman E. P. Yuan W. McEvoy L. Lauerma A. I. Assmann T. Bunemann E. Lehto M. et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation[5] Patel L. Charlton S. J. Chambers J. K. and Macphee C. H. et al. Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations[6] Jarmin D. I. Rits M. Bota D. Gerard N. P. Graham G. J. Clark-Lewis I. Gerard C. Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10 a specific receptor for the chemokine ESkine. [7] Homey B. Wang W. Soto H. Buchanan M. E. Wiesenborn A. Catron D. Muller A. McClanahan T. K. Dieu-Nosjean M. C. Orozco R. et al. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2 CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). [8] Kopatz S. A. Aronstam R. S. Sharma S. V. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [9] Marchese A. Docherty J. M. Nguyen T. Heiber M. Cheng R. Heng H. H. Q. Tsui L. -C. Shi X. George S. R. O\' Dowd B. F. et al. Cloning of human genes encoding novel G protein-coupled receptors. [10] Wang W. Soto H. Oldham E. R. Buchanan M. E. Homey B. Catron D. Jenkins N. Copeland N. G. Gilbert D. J. Nguyen N. et al. Identification of a novel chemokine (CCL28) which binds CCR10 (GPR2).