Trace amine-associated receptor 1

2nd extracellular domain of human. Synthetic peptide - KLH conjugated.
Uses: WB IHC (6 - 15 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: TAAR1 is a G protein-coupled receptor activated by trace amines. Trace amines are endogenous amine compounds that account for less than 1% of the biogenic amines in most brain regions (Bunzow et al. 2001). [supplied by OMIM]. [1] Lindemann L. Ebeling M. Kratochwil N. A. Bunzow J. R. Grandy D. K. and Hoener M. C. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors[2] Bunzow J. R. Sonders M. S. Arttamangkul S. Harrison L. M. Zhang G. Quigley D. I. Darland T. Suchland K. L. Pasumamula S. et al. Amphetamine 3 4-methylenedioxymethamphetamine lysergic acid diethylamide and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor[3] Borowsky B. Adham N. Jones K. A. Raddatz R. Artymyshyn R. Ogozalek K. L. Durkin M. M. Lakhlani P. P. Bonini J. A. et al. Trace amines: identification of a family of mammalian G protein-coupled receptors[4] Borowsky B. Adham N. Jones K. A. Raddatz R. Artymyshyn R. Ogozalek K. L. Durkin M. M. Lakhlani P. P. Bonini J. A. Pathirana S. et al. Trace amines: identification of a family of mammalian G protein-coupled receptors. [5] Bunzow J. R. Sonders M. S. Arttamangkul S. Harrison L. M. Zhang G. Quigley D. I. Darland T. Suchland K. L. Pasumamula S. Kennedy J. L. et al. Amphetamine 3 4-methylenedioxymethamphetamine lysergic acid diethylamide and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. [6] Kopatz S. A. Aronstam R. S. Sharma S. V. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [7] Mungall A. J. Palmer S. A. Sims S. K. Edwards C. A. Ashurst J. L. Wilming L. Jones M. C. Horton R. Hunt S. E. Scott C. E. et al. The DNA sequence and analysis of human chromosome 6. [8] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences. [9] Lindemann L. Ebeling M. Kratochwil N. A. Bunzow J. R. Grandy D. K. Hoener M. C. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.