C-C chemokine receptor-like 2

GWB-DE2B35

Orphan receptor.

Expressed abundantly in immunal tissues such as spleen fetal liver lymph node and bone marrow. Strong expression also in lung and heart. Summary: This protein is a chemokine receptor like protein which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This protein is expressed at high levels in primary neutrophils and primary monocytes and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This protein is mapped to the region where the chemokine receptor gene cluster is located. [1] Galligan C. L. Matsuyama W. Matsukawa A. Mizuta H. Hodge D. R. Howard O. M. and Yoshimura T. Up-regulated expression and activation of the orphan chemokine receptor CCRL2 in rheumatoid arthritis[2] Fan P. Kyaw H. Su K. Zeng Z. Augustus M. Carter K. C. and Li Y. et al. Cloning and characterization of a novel human chemokine receptor[3] Daugherty B. L. and Springer M. S. et al. The beta-chemokine receptor genes CCR1 (CMKBR1) CCR2 (CMKBR2) and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21[4] Fan P. Kyaw H. Su K. Zeng Z. Augustus M. Carter K. C. Li Y. Cloning and characterization of a novel human chemokine receptor. [5] Ansari-Lari M. A. Liu X. -M. Gorrell J. H. Gibbs R. A. Haplotype analysis of a gene cluster containing CCR5 and a new member of chemokine receptor gene family. [6] Gish K. McClanahan T. K. Moore K. W. CRAM: a novel human chemokine receptor-like gene expressed in activated monocytes. [7] Biber K. P. H. Cloning and characterisation of a new MCP-1 chemokine receptor CCR11. [8] Kopatz S. A. Aronstam R. S. Sharma S. V. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [9] Muzny D. M. Scherer S. E. Kaul R. Wang J. Yu J. Sudbrak R. Buhay C. J. Chen R. Cree A. Ding Y. et al. The DNA sequence annotation and analysis of human chromosome 3. [10] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences.