Free fatty acid receptor 1

3rd extracellular domain of human. Synthetic peptide - KLH conjugated.
Uses: WB IHC (15 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. [1] Hardy S. St-Onge G. G. Joly E. Langelier Y. and Prentki M. et al. Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40[2] Ogawa T. Hirose H. Miyashita K. Saito I. and Saruta T. et al. GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men[3] Brown A. J. Jupe S. and Briscoe C. P. et al. A family of fatty acid binding receptors[4] Briscoe C. P. Tadayyon M. Andrews J. L. Benson W. G. Chambers J. K. Eilert M. M. Ellis C. Elshourbagy N. A. Goetz A. S. et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids[5] Itoh Y. Kawamata Y. Harada M. Kobayashi M. Fujii R. Fukusumi S. Ogi K. Hosoya M. Tanaka Y. Uejima H. Tanaka H. et al. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40[6] Sawzdargo M. George S. R. Nguyen T. Xu S. Kolakowski L. F. Jr. O\' Dowd B. F. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13. 1. [7] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences. [8] Briscoe C. P. Tadayyon M. Andrews J. L. Benson W. G. Chambers J. K. Eilert M. M. Ellis C. Elshourbagy N. A. Goetz A. S. Minnick D. T. et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long-chain fatty acids. [9] Tomita T. Masuzaki H. Noguchi M. Iwakura H. Fujikura J. Tanaka T. Ebihara K. Kawamura J. Komoto I. Kawaguchi Y. et al. GPR40 gene expression in human pancreas and insulinoma.