KiSS-1 receptor

3rd cytoplasmic domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Expressed at higher levels in first trimester trophoblasts than at term of gestation.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function and this is supported by the finding that this gene appears to play a role in the onset of puberty. [1] Ikeguchi M. Yamaguchi K. and Kaibara N. et al. Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma[2] Seminara S. B. Messager S. Chatzidaki E. E. Thresher R. R. Acierno J. S. Jr. Shagoury J. K. Bo-Abbas Y. Kuohung W. et al. The GPR54 gene as a regulator of puberty[3] de Roux N. Genin E. Carel J. C. Matsuda F. Chaussain J. L. and Milgrom E. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54[4] Ikeguchi M. Hirooka Y. and Kaibara N. et al. Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma[5] Kotani M. Detheux M. Vandenbogaerde A. Communi D. Vanderwinden J. M. Le Poul E. Brezillon S. Tyldesley R. et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins the natural ligands of the orphan G protein-coupled receptor GPR54[6] Ohtaki T. Shintani Y. Honda S. Matsumoto H. Hori A. Kanehashi K. Terao Y. Kumano S. Takatsu Y. Masuda Y. et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. [7] Clements M. K. McDonald T. P. Wang R. Xie G. O\' Dowd B. F. George S. R. Austin C. P. Liu Q. FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. [8] Muir A. I. Chamberlain L. Elshourbagy N. A. Michalovich D. Moore D. J. Calamari A. Szekeres P. G. Sarau H. M. Chambers J. K. Murdock P. et al. AXOR12 a novel human G protein-coupled receptor activated by the peptide KiSS-1. [9] Kotani M. Detheux M. Vandenbogaerde A. Communi D. Vanderwinden J. -M. Le Poul E. Brezillon S. Tyldesley R. Suarez-Huerta N. Vandeput F. et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins the natural ligands of the orphan G protein-coupled receptor GPR54. [10] Seminara S. B. Messager S. Chatzidaki E. E. Thresher R. R. Acierno J. S. Jr. Shagoury J. K. Bo-Abbas Y. Kuohung W. Schwinof K. M. Hendrick A. G. et al. The GPR54 gene as a regulator of puberty.