Probable G-protein coupled receptor 78

GWB-EF6309

Orphan receptor.

Expressed in pituitary and placenta. No expression detected in brain skeletal muscle lung heart liver pancreas or kidney.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: G protein-coupled receptors (GPCRs or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [supplied by OMIM]. [1] Clark H. F. Gurney A. L. Abaya E. Baker K. Baldwin D. Brush J. Chen J. Chow B. Chui C. Crowley C. Currell B. Deuel B. et al. The secreted protein discovery initiative (SPDI) a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment[2] Lee D. K. Nguyen T. Lynch K. R. Cheng R. Vanti W. B. Arkhitko O. Lewis T. Evans J. F. George S. R. and O\' Dowd B. F. Discovery and mapping of ten novel G protein-coupled receptor genes[3] Lee D. K. Nguyen T. Lynch K. R. Cheng R. Vanti W. B. Arkhitko O. Lewis T. Evans J. F. George S. R. O\' Dowd B. F. et al. Discovery and mapping of ten novel G protein-coupled receptor genes. [4] Suwa M. Sato T. Okouchi I. Arita M. Futami K. Matsumoto S. Tsutsumi S. Aburatani H. Asai K. Akiyama Y. et al. Genome-wide discovery and analysis of human seven transmembrane helix receptor genes. [5] Clark H. F. Gurney A. L. Abaya E. Baker K. Baldwin D. T. Brush J. Chen J. Chow B. Chui C. Crowley C. et al. The secreted protein discovery initiative (SPDI) a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [6] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences. [7] van Laar T. Schouten T. Hoogervorst E. van Eck M. van der Eb A. J. Terleth C. The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway.