Endothelin-1 receptor

GWB-C1453B

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 & gt; ET2 & gt; & gt; ET3.

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. [1] Shirai N. Naruko T. Ohsawa M. Ikura Y. Sugama Y. Hirayama M. Kitabayashi C. Ehara S. Inoue T. Itoh A. Haze K. Tanzawa K. et al. Expression of endothelin-converting enzyme endothelin-1 and endothelin receptors at the site of percutaneous coronary intervention in humans[2] Gallelli L. Pelaia G. D\' Agostino B. Cuda G. Vatrella A. Fratto D. Gioffre V. Galderisi U. De Nardo M. Mastruzzo C. et al. Endothelin-1 induces proliferation of human lung fibroblasts and IL-11 secretion through an ET(A) receptor-dependent activation of MAP kinases[3] Gormley K. Bevan S. Hassan A. and Markus H. S. et al. Polymorphisms in genes of the endothelin system and cerebral small-vessel disease[4] Paasche J. D. Attramadal T. Kristiansen K. Oksvold M. P. Johansen H. K. Huitfeldt H. S. Dahl S. G. and Attramadal H. Subtype-specific sorting of the ETA endothelin receptor by a novel endocytic recycling signal for G protein-coupled receptors[5] Ishikawa K. Funayama T. Ohtake Y. Kimura I. Ideta H. Nakamoto K. Yasuda N. Fukuchi T. Fujimaki T. Murakami A. et al. Association between glaucoma and gene polymorphism of endothelin type A receptor[6] Adachi M. Yang Y. Y. Furuichi Y. Miyamoto C. Cloning and characterization of cDNA encoding human A-type endothelin receptor. [7] Cyr C. Huebner K. Druck T. Kris R. Cloning and chromosomal localization of a human endothelin ETA receptor. [8] Hosoda K. Nakao K. Arai H. Suga S. Ogawa Y. Mukoyama M. Shirakami G. Saito Y. Nakanishi S. Imura H. et al. Cloning and expression of human endothelin-1 receptor cDNA. [9] Arai H. Nakao K. Hosoda K. Ogawa Y. Nakagawa O. Komatsu Y. Imura H. Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells. [10] Elshourbagy N. A. Korman D. R. Wu H. L. Sylvester D. R. Lee J. A. Nuthalaganti P. Bergsma D. J. Kumar C. S. Nambi P. Molecular characterization and regulation of the human endothelin receptors.