G-protein coupled receptor family C group 5 member B

GWB-7DC5B9

Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

Expression is high in kidney pancreas and testis medium in brain heart prostate small intestine and spleen low in liver placenta skeletal muscle colon ovary and thymus and not detectable in lung and peripheral leukocyte. According to Ref. 2: highly expressed in most brain areas examined with the highest levels observed in corpus callosum caudate nucleus putamen substantia nigra thalamus hippocampus and spinal chord as well as in dorsal root ganglia (DRG). In the periphery expression levels are relatively low compared to the CNS with the strongest expression detected in pancreas testis uterus and stomach.

Belongs to the G-protein coupled receptor 3 family [view classification]. Summary: The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. [1] Otsuki T. Ota T. Nishikawa T. Hayashi K. Suzuki Y. Yamamoto J. Wakamatsu A. Kimura K. Sakamoto K. Hatano N. et al. Signal Sequence and Keyword Trap in silico for Selection of Full-Length Human cDNAs Encoding Secretion or Membrane Proteins from Oligo-Capped cDNA Libraries[2] Robbins M. J. Michalovich D. Hill J. Calver A. R. Medhurst A. D. Gloger I. Sims M. Middlemiss D. N. and Pangalos M. N. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)[3] Brauner-Osborne H. and Krogsgaard-Larsen P. et al. Sequence and expression pattern of a novel human orphan G-protein-coupled receptor GPRC5B a family C receptor with a short amino-terminal domain[4] Loftus B. J. Kim U. J. Sneddon V. P. Kalush F. Brandon R. Fuhrmann J. Mason T. Crosby M. L. Barnstead M. Cronin L. et al. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q[5] Braeuner-Osborne H. Krogsgaard-Larsen P. Sequence and expression pattern of a novel human orphan G-protein-coupled receptor GPRC5B a family C receptor with a short amino-terminal domain. [6] Robbins M. J. Michalovich D. Hill J. Calver A. R. Medhurst A. D. Gloger I. Sims M. A. Middlemiss D. N. Pangalos M. N. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). [7] Wei H. Osborne B. Spruyt M. Murphy D. Cloning of a novel G protein-coupled receptor localized on human chromosome 16p12. [8] Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. et al. Complete sequencing and characterization of 21 243 full-length human cDNAs. [9] Adams M. D. Loftus B. J. Zhou L. Crosby M. Fuhrmann J. Mason T. M. Brandon R. Kim U. J. Kerlavage A. R. Venter J. C. et al. Homo sapiens chromosome 16 BAC clone CIT987SK-A-69G12. [10] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences.