Muscarinic acetylcholine receptor M3

GWB-8EC0B5

The muscarinic acetylcholine receptor mediates various cellular responses including inhibition of adenylate cyclase breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition phosphoinositide degeneration and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [1] Goin J. C. and Nathanson N. M. et al. Quantitative analysis of muscarinic acetylcholine receptor homo- and heterodimerization in live cells: regulation of receptor down-regulation by heterodimerization[2] Novi F. Stanasila L. Giorgi F. Corsini G. U. Cotecchia S. and Maggio R. Paired activation of two components within muscarinic M3 receptor dimers is required for recruitment of beta-arrestin-1 to the plasma membrane[3] Marczinovits I. Kovacs L. Gyorgy A. Toth G. K. Dorgai L. Molnar J. and Pokorny G. A peptide of human muscarinic acetylcholine receptor 3 is antigenic in primary Sjogren\' s syndrome[4] Otsuki T. Ota T. Nishikawa T. Hayashi K. Suzuki Y. Yamamoto J. Wakamatsu A. Kimura K. Sakamoto K. Hatano N. et al. Signal Sequence and Keyword Trap in silico for Selection of Full-Length Human cDNAs Encoding Secretion or Membrane Proteins from Oligo-Capped cDNA Libraries[5] Metzger M. Just L. Boss A. and Drews U. et al. Identification and functional characterization of the muscarinic receptor M3 in the human keratinocyte cell line HaCaT[6] Peralta E. G. Ashkenazi A. Winslow J. W. Smith D. H. Ramachandran J. Capon D. J. Distinct primary structures ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. [7] Bonner T. I. Young A. C. Brann M. R. Buckley N. J. Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. [8] Kitano T. Kobayakawa H. Saitou N. Silver project. [9] Puhl H. L. III Ikeda S. R. Aronstam R. S. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [10] Gregory S. G. Barlow K. F. McLay K. E. Kaul R. Swarbreck D. Dunham A. Scott C. E. Howe K. L. Woodfine K. Spencer C. C. A. et al. The DNA sequence and biological annotation of human chromosome 1.