Probable G-protein coupled receptor 4

GWB-FF0EB7

Orphan receptor.

Belongs to the G-protein coupled receptor 1 family [view classification]. [1] Kim K. S. Ren J. Jiang Y. Ebrahem Q. Tipps R. Cristina K. Xiao Y. J. Qiao J. Taylor K. L. Lum H. Anand-Apte B. and Xu Y. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine[2] Sin W. C. Zhang Y. Zhong W. Adhikarakunnathu S. Powers S. Hoey T. An S. and Yang J. G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers[3] Bektas M. Barak L. S. Jolly P. S. Liu H. Lynch K. R. Lacana E. Suhr K. B. Milstien S. and Spiegel S. The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner[4] Lum H. Qiao J. Walter R. J. Huang F. Subbaiah P. V. Kim K. S. and Holian O. Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells[5] Ludwig M. G. Vanek M. Guerini D. Gasser J. A. Jones C. E. Junker U. Hofstetter H. Wolf R. M. and Seuwen K. Proton-sensing G-protein-coupled receptors[6] Heiber M. Docherty J. M. Shah G. Nguyen T. Cheng R. Heng H. H. Q. Marchese A. Tsui L. -C. Shi X. George S. R. et al. Isolation of three novel human genes encoding G protein-coupled receptors. [7] Mahadevan M. S. Baird S. Bailly J. E. Shutler G. G. Sabourin L. A. Tsilfidis C. Neville C. E. Narang M. Korneluk R. G. Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13. 3. [8] An S. Tsai C. Goetzl E. J. Cloning sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue. [9] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences.