Alpha-2C adrenergic receptor

2nd extracellular domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (15 - 30 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A alpha2B and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This protein is the alpha2C subtype which contains no introns in either its coding or untranslated sequences. [1] Neumeister A. Charney D. S. Belfer I. Geraci M. Holmes C. Sharabi Y. Alim T. Bonne O. Luckenbaugh D. A. Manji H. et al. Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans[2] Chotani M. A. Mitra S. Eid A. H. Han S. A. and Flavahan N. A. et al. Distinct cAMP signaling pathways differentially regulate alpha2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells[3] Belfer I. Buzas B. Hipp H. Phillips G. Taubman J. Lorincz I. Evans C. Lipsky R. H. Enoch M. A. Max M. B. and Goldman D. Haplotype-based analysis of alpha 2A 2B and 2C adrenergic receptor genes captures information on common functional loci at each gene[4] Small K. M. Mialet-Perez J. Seman C. A. Theiss C. T. Brown K. M. and Liggett S. B. Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects[5] Chotani M. A. Mitra S. Su B. Y. Flavahan S. Eid A. H. Clark K. R. Montague C. R. Paris H. Handy D. E. and Flavahan N. A. Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells[6] Regan J. W. Kobilka T. S. Yang-Feng T. L. Caron M. G. Lefkowitz R. J. Kobilka B. K. Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. [7] Schaak S. Devedjian J. C. Cayla C. Sender Y. Paris H. Molecular cloning sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene. [8] Yano K. Takeda M. Sugimoto E. Sagai H. Molecular cloning and expression of a novel human alpha2C-adrenerginc receptor alpha2CII gene. [9] Small K. M. Forbes S. L. Rahman F. F. Bridges K. M. Liggett S. B. A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors. [10] Small K. M. Mialet-Perez J. Seman C. A. Theiss C. T. Brown K. M. Liggett S. B. Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.