Histamine receptor H4

3rd cytoplasmic domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (7 - 14 ug/ml) (Optimal dilution to be determined by the researcher)

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: Histamine is a ubiquitous messenger molecule released from mast cells enterochromaffin-like cells and neurons. Its various actions are mediated by histamine receptors H1 H2 H3 and H4. Histamine receptor H4 belongs to the family 1 of G protein-coupled receptors and has the highest homology to histamine receptor H3 among known G protein-coupled receptors. [1] Cianchi F. Cortesini C. Schiavone N. Perna F. Magnelli L. Fanti E. Bani D. Messerini L. Fabbroni V. Perigli G. et al. The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer[2] Nakayama T. Kato Y. Hieshima K. Nagakubo D. Kunori Y. Fujisawa T. and Yoshie O. Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor[3] Lippert U. Artuc M. Grutzkau A. Babina M. Guhl S. Haase I. Blaschke V. Zachmann K. Knosalla M. Middel P. et al. Human skin mast cells express H2 and H4 but not H3 receptors[4] Coge F. Guenin S. P. Rique H. Boutin J. A. and Galizzi J. P. et al. Structure and expression of the human histamine H4-receptor gene[5] Morse K. L. Behan J. Laz T. M. West R. E. Jr. Greenfeder S. A. Anthes J. C. Umland S. Wan Y. Hipkin R. W. Gonsiorek W. Shin N. et al. Cloning and characterization of a novel human histamine receptor[6] Nguyen T. Shapiro D. A. George S. R. Setola V. Lee D. K. Cheng R. Rauser L. Lee S. P. Lynch K. R. Roth B. L. et al. Discovery of a novel member of the histamine receptor family.