Neuromedin-B receptor

GWB-97A3E7

Receptor for neuromedin-B.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: Neuromedin B receptor binds neuromedin B a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue. [1] Matusiak D. Glover S. Nathaniel R. Matkowskyj K. Yang J. and Benya R. V. Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon[2] Lee S. and Kim Y. et al. Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy[3] Sainz E. Akeson M. Mantey S. A. Jensen R. T. and Battey J. F. et al. Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor[4] Kane M. A. Toi-Scott M. Johnson G. L. Kelley K. K. Boose D. and Escobedo-Morse A. Bombesin-like peptide receptors in human bronchial epithelial cells[5] Wu J. M. Hoang D. O. and Feldman R. I. et al. Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs[6] Corjay M. H. Dobrzanski D. J. Way J. M. Viallet J. Shapira H. Worland P. Sausville E. A. Battey J. F. Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.