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Rabbit anti Caspase 7 (CT)

Rabbit anti Caspase 7 (CT)

Catalytic
Item no.	18-511-244416
Manufacturer	GENWAY
Amount	0,1 mg
Category	Oncology Antibodies By Cell Type Carcinoma Cell Biology Cell Status Apoptosis Western Blot Primary Antibodies By Organ Lung Cancer
Type	Antibody
Applications	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3B394F
Similar products	18-511-244416
Available
Genway ID:	GWB-3B394F
Host Animal:	Rabbit
Immunogen:	16 amino acid peptide from near the carboxy-terminus of human Caspase-7 (Genbank accession No. P55210).
Specificity:	Caspase 7 C-terminal
Specificity:	Reacts with human mouse and rat Caspase-7 C-terminal. Depending on cell lines or tissues used either full length or other cleavage products may be observed.
Type of Product:	Polyclonal Antibodies to Apoptosis and Signal Transduction Reagents
Concentration:	Lot specificPreservatives: NaN3
Buffer:	PBSApplications Notes : Suitable for use in Western blot (0. 5ug/ml) and immunohistochemistry (2ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Rabbit anti Caspase 7 (CT). Rabbit Antibody to Human Caspase-7 C-terminal
Function:	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a \' 216-Asp-\|-Gly-217\' bond. Overexpression promotes programmed cell death.
Activity:	Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-\|-.
Enzyme Regulation:	Inhibited by isatin sulfonamides.
Subunit:	Heterotetramer that consists of two anti-parallel arranged heterodimers each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit.
Subcellular Location:	Cytoplasm.
Tissue Specificity:	Highly expressed in lung skeletal muscle liver kidney spleen and heart and moderately in testis. No expression in the brain.
Ptm:	Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3 and vice versa also occur.
Similarity:	Belongs to the peptidase C14A family [view classification].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0,1 mg

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Delivery expected until 9/11/2025

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