Sheep anti Complement C1q

GWB-4F32D0

Human C1q & gt; 95% pure (SDS-PAGE). Prepared from human plasma

Gives a single arc when tested by IEP against fresh human plasma. Identity has been confirmed by double diffusion (Ouchterlony) against fresh human plasma and a known anti-human C1q. C1q is a sub-component of the first complement component C1 which is formed by the interaction of C1q with the tetramer C1s-C1r-C1r-C1s. C1q is a member of a family of soluble collagen-like proteins and is composed of three basic subunits termed A B and C (27 550 25 200 23 800 Da-respectively) which associate in the proportion 6A-B subunits (52 750 Da) and 3 C-C subunits (47 600 Da) to form whole C1q (459 300 Da). C1q binds to IgG and IgM immune complexes this activates C1r and C1s which are also bound to C1q and so initiates the classical pathway of complement activation. The normal plasma concentration of C1q is 100-180 mg/L.

14. 98 mg/ml. (OD280nm E1% = 14. 5)Preservatives: 0. 099% NaN3 0. 1% EACA 0. 01% Benzamidine 1mM EDTA

Results can be enhanced by washing completed agarose gels in saline drying and finally staining with a protein stain such as coomassie blue. . RID: 0. 1ul antiserum/cm2 in gel vs 20ul fresh plasma Neat-1:2. Double Dif

This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1& acirc; ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Sheep anti Complement C1q. Sheep Antibody to Human Complement C1q

C1 is a calcium-dependent trimolecular complex of C1q R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits six of which are disulfide-linked dimers of the A and B chains and three of which are disulfide-linked dimers of the C chain.

O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups (By similarity).

Contains 1 C1q domain.