Glutamate

GWB-261664

Specific for ~180k NMDAR NR2B subunit protein phosphorylated at Tyr1336. eling of the NMDAR NR2B subunit band is blocked by l-phosphatase treatment.

Forms heteromeric channel of a zeta subunit (GRIN1) a epsilon subunit (GRIN2A GRIN2B GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 GRIN3A and PPP2CB. Found in a complex with GRIN1 and GRIN3B (By similarity). Interacts with PDZ domains of INADL and DLG4.

Belongs to the glutamate-gated ion channel (TC 1. A. 10) family [view classification]. Summary: subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium calcium permeability and glycine regulated activity; may facilitate learning and long term potentiation [RGD]. [1] Zhou M. and Baudry M. et al. Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors[2] Gardoni F. Picconi B. Ghiglieri V. Polli F. Bagetta V. Bernardi G. Cattabeni F. Di Luca M. and Calabresi P. A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia[3] Bayer K. U. LeBel E. McDonald G. L. O\' Leary H. Schulman H. and De Koninck P. Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B[4] Yang J. Woodhall G. L. and Jones R. S. et al. Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats[5] Habas A. Kharebava G. Szatmari E. and Hetman M. et al. NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3beta-induced apoptosis[6] Monyer H. Sprengel R. Schoepfer R. Herb A. Higuchi M. Lomeli H. Burnashev N. Sakmann B. Seeburg P. H. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. [7] Sullivan J. M. Traynelis S. F. Chen H. S. Escobar W. Heinemann S. F. Lipton S. A. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. [8] Kornau H. C. Schenker L. T. Kennedy M. B. Seeburg P. H. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. [9] Kurschner C. Mermelstein P. G. Holden W. T. Surmeier D. J. CIPP a novel multivalent PDZ domain protein selectively interacts with Kir4. 0 family members NMDA receptor subunits neurexins and neuroligins. [10] Chan S. F. Sucher N. J. An NMDA receptor signaling complex with protein phosphatase 2A.