RABBIT ANTI WNV CORE PROTEIN (C-TERMINAL)

GWB-F7C869

Polyclonal IgG

Recognises the 14kDa core protein of West Nile Virus (WNV). WNV belongs to the Flaviviridae family which includes closely viruses such as Dengue fever Yellow fever and Tick borne encephalitis. West Nile Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope containing envelope and matrix proteins. Research indicates that the viral core protein contributes to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway. West Nile Virus is believed to have originated in the West Nile region of Africa and has now spread to Europe Asia and America where it has become a significant disease affecting human and domestic animal health. Recommended Secondary Antibodies: Sheep Anti Rabbit IgGGoat Anti Rabbit IgG (Fc)Goat Anti Rabbit IgG (H/L)

The virion of this virus is a nucleocapsid covered by a lipoprotein envelope. The envelope contains two proteins: the protein M and glycoprotein E. The nucleocapsid is a complex of protein C and mRNA. In immature particles there are 60 icosaedrally organized trimeric spikes on the surface. Each spike consists of three heterodimers of envelope protein M precursor (prM) and envelope protein E By similarity. Sequence similaritiesContains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 peptidase S7 domain. Contains 1 RdRp catalytic domain. 1. Madersbacher S. et al. (1992) Free alpha-subunit free beta-subunit of human chorionic gonadotropin (hCG) and intact hCG in sera of healthy individuals and testicular cancer patients. Clin Chem. 38: 370-376. 2. Madersbacher S. et al. (1993) Serum glycoprotein hormones and their free alpha-subunit in a healthy elderly population selected according to the SENIEUR protocol. Analyses with ultrasensitive time resolved fluoroimmunoassays. Mech Ageing Dev. 71: 223-233. [1] \" Isolation cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin. \" Fiddes J. C. Goodman H. M. Nature 281:351-356(1979) [PubMed: 481597] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [2] \" Structure and regulation of human thyroid-stimulating hormone (TSH) gene. \" Miyoshi I. Kasai N. Hayashizaki Y. Nippon Rinsho 52:940-947(1994) [PubMed: 8196184] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [3] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. [4] \" The gene encoding the common alpha subunit of the four human glycoprotein hormones. \" Fiddes J. C. Goodman H. M. J. Mol. Appl. Genet. 1:3-18(1981) [PubMed: 6286817] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98. [5] \" The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin. \" Birken S. Fetherston J. Canfield R. E. Boime I. J. Biol. Chem. 256:1816-1823(1981) [PubMed: 7462224] [Abstract]Cited for: PROTEIN SEQUENCE OF 1-24. [6] \" Human pituitary thyrotropin. The primary structure of the alpha and beta subunits. \" Sairam M. R. Li C. H. Can. J. Biochem. 55:755-760(1977) [PubMed: 890569] [Abstract]Cited for: PROTEIN SEQUENCE OF 28-116. [7] \" Human pituitary interstitial cell stimulating hormone: primary structure of the alpha-subunit. \" Sairam M. R. Papkoff H. Li C. H. Biochem. Biophys. Res. Commun. 48:530-537(1972) [PubMed: 5065401] [Abstract]Cited for: PROTEIN SEQUENCE OF 28-116. [8] \" Structure of human luteninizing hormone. \" Keutmann H. T. Williams R. M. Bishop W. H. Ryan R. J. Fed. Proc. 37:1828-1828(1978)Cited for: PROTEIN SEQUENCE SEQUENCE REVISION. [9] \" Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit. \" Rathnam P. Saxena B. B. J. Biol. Chem. 250:6735-6746(1975) [PubMed: 1158880] [Abstract]Cited for: PROTEIN SEQUENCE OF 25-116. Tissue: Pituitary. [10] \" Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa). \" Shome B. Parlow A. F. J. Clin. Endocrinol. Metab. 39:199-202(1974) [PubMed: 4835135] [Abstract]Cited for: PROTEIN SEQUENCE OF 28-116.