RABBIT ANTI CASPASE-7 (N-TERMINAL)

CASPASE-7 (N-TERMINAL)

Phosphate buffered saline

A 16 amino acid peptide from human Caspase-7 amino-terminus

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a \' 216-Asp-|-Gly-217\' bond. Overexpression promotes programmed cell death. Catalytic activityStrict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-. Enzyme regulationInhibited by isatin sulfonamides. Subunit structureHeterotetramer that consists of two anti-parallel arranged heterodimers each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Ref. 13Subcellular locationCytoplasm. Tissue specificityHighly expressed in lung skeletal muscle liver kidney spleen and heart and moderately in testis. No expression in the brain. Post-translational modificationCleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3 and vice versa also occur. Ref. 10Sequence similaritiesBelongs to the peptidase C14A family. 1. Greenman J. et al. (1991) Characterisation of a new monoclonal anti-Fc gamma RII antibody AT10 and its incorporation into a bispecific F(ab\' )2 derivative for recruitment of cytotoxic effectors. Mol. Immunol. 28: 1243-1254. 2. van den Herik-Oudijk I. E. et al. (1994) Functional analysis of human Fc gamma RII (CD32) isoforms expressed in B lymphocytes. J. Immunol. 152: 574-585. 3. Lilliehook I. et al. (1998) Expression of adhesion and Fc gamma - receptors on canine blood eosinophils and neutophils studied by anti-human monoclonal antibodies. Vet. Immunol. Immunopathol. 61: 181-193. 4. Larsson M. et al. (1997) Human dendritic cells handling of binding uptake and degradation of free and IgG - immune complexed dinitrophenylated human serum albumin in vitro. Immunology. 90: 138-146. 5. Dutertre C- A. et al. (2008) A novel subset of NK cells expressing high levels of inhibitory FcgammaRIIB modulating antibody-dependent function. Journal of Leukocyte Biology. 84: 1511-1519. 6. Devriendt B. et al. (2010) Targeting of Escherichia coli F4 fimbriae to Fcgamma receptors enhances the maturation of porcine dendritic cells. Vet Immunol Immunopathol. 135: 188-98. [1] \" Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII). \" Stuart S. G. Trounstine M. L. Vaux D. J. T. Koch T. Martens C. L. Moore K. W. J. Exp. Med. 166:1668-1684(1987) [PubMed: 2824655] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANT ARG-167. [2] \" Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. \" Brooks D. G. Qiu W. Q. Luster A. D. Ravetch J. V. J. Exp. Med. 170:1369-1385(1989) [PubMed: 2529342] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANT ARG-167. [3] \" The DNA sequence and biological annotation of human chromosome 1. \" Gregory S. G. Barlow K. F. McLay K. E. Kaul R. Swarbreck D. Dunham A. Scott C. E. Howe K. L. Woodfine K. Spencer C. C. A. Jones M. C. Gillson C. Searle S. Zhou Y. Kokocinski F. McDonald L. Evans R. Phillips K. Atkinson A. Cooper R. Jones C. Hall R. E. Andrews T. D. Lloyd C. Ainscough R. Almeida J. P. Ambrose K. D. Anderson F. Andrew R. W. Ashwell R. I. S. Aubin K. Babbage A. K. Bagguley C. L. Bailey J. Beasley H. Bethel G. Bird C. P. Bray-Allen S. Brown J. Y. Brown A. J. Buckley D. Burton J. Bye J. Carder C. Chapman J. C. Clark S. Y. Clarke G. Clee C. Cobley V. Collier R. E. Corby N. Coville G. J. Davies J. Deadman R. Dunn M. Earthrowl M. Ellington A. G. Errington H. Frankish A. Frankland J. French L. Garner P. Garnett J. Gay L. Ghori M. R. J. Gibson R. Gilby L. M. Gillett W. Glithero R. J. Grafham D. V. Griffiths C. Griffiths-Jones S. Grocock R. Hammond S. Harrison E. S. I. Hart E. Haugen E. Heath P. D. Holmes S. Holt K. Howden P. J. Hunt A. R. Hunt S. E. Hunter G. Isherwood J. James R. Johnson C. Johnson D. Joy A. Kay M. Kershaw J. K. Kibukawa M. Kimberley A. M. King A. Knights A. J. Lad H. Laird G. Lawlor S. Leongamornlert D. A. Lloyd D. M. Loveland J. Lovell J. Lush M. J. Lyne R. Martin S. Mashreghi-Mohammadi M. Matthews L. Matthews N. S. W. McLaren S. Milne S. Mistry S. Moore M. J. F. Nickerson T. O\' Dell C. N. Oliver K. Palmeiri A. Palmer S. A. Parker A. Patel D. Pearce A. V. Peck A. I. Pelan S.