RABBIT ANTI PPAR GAMMA

GWB-2253AA

Polyclonal IgGSpecies Cross Reactivity: Reacts with: Mouse Dog PigN. B. Antibody reactivity and working conditions may vary between species.

Recognises Human Peroxisome proliferator-activated receptor gamma (PPAR gamma) a 57. 6kDa transcription factor belonging to the nuclear hormone receptor (NR1) family. PPARG is vital in the regulation of cellular differentiation development and metabolism. PPARG is a key regulator of adipocyte differentiation and glucose homeostasis. In addition PPARG is the main target of thiazolidinediones (TZDs) a class of drug used in diabetes mellitus and other diseases that feature insulin resistance. PPARG is widely expressed with high concentrations being found in adipose tissue. Recommended Secondary Antibodies: Sheep Anti Rabbit IgGGoat Anti Rabbit IgG (Fc)Goat Anti Rabbit IgG (H/L)

Genetic variation in PPARG may influence body mass index (BMI) [MIM:606641]. BMI reflects the amount of fat lean mass and body build. Involvement in diseaseNote=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity [MIM:601665]. Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance diabetes mellitus and dyslipidemia. Ref. 40Ref. 41Variation in PPARG is associated with carotid intimal medial thickness 1 (CIMT1) [MIM:609338]. CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors. Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas glioblastoma multiforme oligodendrogliomas and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility. Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. Sequence cautionThe sequence AAN38992. 2 differs from that shown. Reason: Erroneous initiation. The sequence BAA23354. 1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAF83270. 1 differs from that shown. Reason: Erroneous initiation. The sequence CAA62153. 1 differs from that shown. Reason: Erroneous initiation. [1] \" Amgen rat EST program. \" Amgen EST programSubmitted (MAY-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-147 (ISOFORM 4). [2] \" Lymphocyte specific heterogeneity in the rat leucocyte common antigen (T200) is due to differences in polypeptide sequences near the NH2-terminus. \" Barclay A. N. Jackson D. I. Willis A. C. Williams A. F. EMBO J. 6:1259-1264(1987) [PubMed: 2440674] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-218 (ISOFORMS 1; 2; 3 AND 4). [3] Barclay A. N. Jackson D. I. Willis A. C. Williams A. F. Submitted (MAY-1987) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-1273 (ISOFORMS 1; 3; 4 AND 5). [4] \" Evidence from cDNA clones that the rat leukocyte-common antigen (T200) spans the lipid bilayer and contains a cytoplasmic domain of 80 000 Mr. \" Thomas M. L. Barclay A. N. Gagnon J. Williams A. F. Cell 41:83-93(1985) [PubMed: 3158393] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-1255 (ISOFORM 1).