RABBIT ANTI GAPDH (N-TERMINAL)

GAPDH (N-TERMINAL)

Phosphate buffered saline

A peptide corresponding to a 16 amino acid sequence from near the amino-terminus of GAPDH.

Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway. Ref. 22Catalytic activityD-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.

Postnuclear and Perinuclear regions. Ref. 23Post-translational modificationReversible S-nitrosylation of Cys-152 inhibits enzymatic activity and increases endogenous ADP-ribosylation which inhibits the enzyme in a non-reversible manner. The latter modification is more likely to be a pathophysiological event associated with inhibition of gluconeogenesis By similarity. ISGylated Probable. Ref. 28Sequence similaritiesBelongs to the glyceraldehyde-3-phosphate dehydrogenase family. Sequence cautionThe sequence described in Ref. 16 differs from that shown. Reason: Differs quite extensively. 1. Skarstein K. et al. (1994) Oligoclonality of T cells in salivary glands of autoimmune MRL/lpr mice. Immunology 81: 497-501. 2. Van der Heyde H. C. et al. (1995) Gamma/delta T cells function in cell mediated immunity to acute blood-stage plasmodium chabaudi adami Malaria. J. Immunol. 154: 3985 - 3990. 3. Skeen M. J. and Ziegler H. K. (1993) Induction of murine peritoneal gamma/delta T cells and their role in resistance to bacterial infection. J. Exp. Med. 178: 971 - 984. 4. Karasova D. et al. (2010) Influence of 5 major Salmonella pathogenicity islands on NK cell depletion in mice infected with Salmonella enterica serovar Enteritidis. BMC Microbiol. 10: 75.