SHEEP ANTI METHAQUALONE

METHAQUALONE

Purified IgG prepared by caprylic acid and ammonium sulphate precipitation

Recognises Methaqualone a sedative drug similar to barbiturates. It also has anti-convulsant antispasmodic anaesthetic and antihistamines properties. It was used in the 1960\' s and 1970\' s as a barbiturate substitute for the treatment of insomnia and as a sedative and muscle relaxant. It has since been withdrawn from many developed markets and is no longer legally produced. It is used illegally as a recreational drug leading to tolerance dependence and withdrawal symptoms. It may be combined with diphenhydramine cannabis or tobacco and smoked to give a feeling of trance-like euphoria. The practice poses a serious heath risk and may lead to emphysema and other chronic lung disorders. Recommended Secondary Antibodies: Rabbit Anti Sheep IgG (H/L)Donkey Anti Sheep IgG 1. Wibulswas A. et al. (2000) The CD44v7/8 epitope as a target to restrain proliferation of fibroblast like synoviocytes in rheumatoid arthritis. Am. J. Pathol. 157: 2037-2044. 2. Alam T. N. et al. (2004) Differential expression of CD44 during human prostate epithelial cell differentiation. J Histochem Cytochem. 52: 1083-90. [1] \" A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. \" Stamenkovic I. Amiot M. Pesando J. M. Seed B. Cell 56:1057-1062(1989) [PubMed: 2466575] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12). [2] \" The multispecific cell adhesion molecule CD44 is represented in reticulocyte cDNA. \" Harn H. -J. Isola N. Cooper D. L. Biochem. Biophys. Res. Commun. 178:1127-1134(1991) [PubMed: 1840487] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12). Tissue: Reticulocyte. [3] \" The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. \" Stamenkovic I. Aruffo A. Amiot M. Seed B. EMBO J. 10:343-348(1991) [PubMed: 1991450] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10). [4] \" Molecular cloning of CD44R1 and CD44R2 two novel isoforms of the human CD44 lymphocyte \' homing\' receptor expressed by hemopoietic cells. \" Dougherty G. J. Lansdorp P. M. Cooper D. L. Humphries R. K. J. Exp. Med. 174:1-5(1991) [PubMed: 2056274] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10 AND 11). Tissue: Myeloid leukemia cell. [5] \" The core protein of epican a heparan sulfate proteoglycan on keratinocytes is an alternative form of CD44. \" Kugelman L. C. Ganguly S. Haggerty J. G. Weissman S. M. Milstone L. M. J. Invest. Dermatol. 99:886-891(1992) [PubMed: 1281868] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4) VARIANT LYS-417. Tissue: Keratinocyte. [6] \" Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. \" Screaton G. R. Bell M. V. Jackson D. G. Cornelis F. B. Gerth U. Bell J. I. Proc. Natl. Acad. Sci. U. S. A. 89:12160-12164(1992) [PubMed: 1465456] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] ALTERNATIVE SPLICING. Tissue: Lymphoblast. [7] \" CD44: a multitude of isoforms with diverse functions. \" Gunthert U. Curr. Top. Microbiol. Immunol. 184:47-63(1993) [PubMed: 7508842] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANT HIS-494. [8] \" Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase. \" Tanabe K. K. Nishi T. Saya H. Mol. Carcinog. 7:212-220(1993) [PubMed: 8352881] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 13 AND 14). Tissue: Mammary carcinoma. [9] \" CD44 in normal and neoplastic human cartilage. \" Bosch P. P. Stevens J. W. Buckwalter J. A. Midura R. J. Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12). Tissue: Articular cartilage. [10] \" Sequence analysis of the human CD44 antigen. \" Wiebe G. J. Freund D. Corbeil D. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10 AND 12). Tissue: Colon adenocarcinoma and Retinal pigment epithelium.