USP4


Item no.	18-783-75524
Manufacturer	GENWAY
Amount	0.05 mg
Category	Oncology Antibodies Immunohistochemistry Primary Antibodies By Organ Lung Cancer
Type	Antibody
Applications	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D65D08
Similar products	18-783-75524
Available
Genway ID:	GWB-D65D08
Specificity:	USP4NCBI
Gene ID:	7375
Specificity:	USP4
Immunogen:	Synthetic peptide: Internal domain of human USP4.
Specificity Note:	This product detects an epitope within the internal region of ubiquitin specific protease 4 (USP4) a 105kD protein also known as ubiquitous nuclear protein (UNP). USP4 binds to the retinoblastoma family of tumour suppressor proteins including pRb p107 and p130. USP4 shuttles between the nucleus and cytoplasm and is thought to be an oncogene with elevated expression in small cells tumours and adenocarcinomas of the lung. Histology: Thymus
Antiserum Preparation:	Antisera to USP4 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 02%Sodium Azide (NaN3) Suggested
Dilution:	Suggested
Dilution:	Immunohistology - Paraffin - 5 - 10ug/ml
Catalytic Activity:	Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
Subcellular Location:	Cytoplasm.
Similarity:	Belongs to the peptidase C19 family [view classification].
Similarity:	Contains 1 DUSP domain. 1. Blanchette. P. et al. (2001) Association of UNP. a ubiquitin-specific protease. with the pocket proteins pRb. p107 and p130. 2. Soboleva. T. A. et al. (2005) Nuclear-Cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme. 3. DeSalle. L. M. et al. (2001) The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 mg

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Delivery expected until 11/27/2025

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