CTRP6

114904

CTRP6 (C-Terminal).

This product detects an epitope within the C-terminal (CT) region of human C1q and TNF related protein 6 (CTRP6) also known as C1QTNF6. CTRP6 is an adipokine; proteins which are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. CTRP6 is highly post-translationally modified containing at least 4 glycosylation motifs. It has a predicted molecular weight of 29kD and an observed molecular weight of 42kD. Histology: HeLa cells.

Phosphate buffered saline

Western Blot: This product detects a band of approximately 42kDa in heLa cell lysates. These proteins often migrate in SDS-PAGE at positions other that their predicted size. Suggested

Interacts with tubulin alpha ACTN2 ANKHD1 ATF4 ATF5 CEP63 EIF3S3 MAP1A NDEL1 PAFAH1B1 RANBP9 SPTBN4 SYNE1 and TRAF3IP1. Interaction with microtubules may be mediated in part by TRAF3IP1.

Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter. Developmental Stage: Expression rises within the dentate gyrus and temporal cortex from the neonatal period to infancy declines markedly in adolescence and declines further with aging.

Genetic variation in DISC1 may be associated with susceptibility to schizophrenia 9 (SCZD9) [MIM:604906]. Schizophrenia [MIM:181500] is a psychosis a disorder of thought and sense of self. Although it affects emotions it is distinguished from mood disorders in which such disturbances are primary. Similarly there may be mild impairment of cognitive function and it is distinguished from the dementias in which disturbed cognitive function is considered primary. No objective biological test for schizophrenia exists. Schizophrenia is a common disorder with a lifetime prevalence of approximately 1%. It is highly heritable but the genetics are complex.