CRMP2

Item no.	18-783-75674
Manufacturer	GENWAY
Amount	0.1 ml
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Antibodies Western Blot ELISA Primary Antibodies
Type	Antibody
Applications	WB, ELISA
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-269DDF
Similar products	18-783-75674
Available
Genway ID:	GWB-269DDF
Specificity:	CRMP2 NCBI
Gene ID:	1808
Specificity:	CRMP2
Immunogen:	Synthetic peptide corresponding amino acid sequence 543-557 of human CRMP2.
Specificity Note:	This product recognises collapsin response mediator protein 2 (CRMP2) a ubiquitously expressed 62 kDa member of the dehydropyrimidinase family. It is involved in axon formation and outgrowth by transporting to axons the actin cytoskeleton regulating; Rac1-associated protein 1 (Sra-1)/WASP family verprolin-homologous protein 1 (WAVE1) complex. CRMP2 also regulates axon formation and branching by binding tubulin heterodimers thereby enhancing microtubule polymerisation. Through its interaction with ROKalpha CRMP2 is also thought to play a role in RhoA-dependent signalling. CRMP2 is associated with mesial temporal lobe epilepsy and schizophrenia.
Antiserum Preparation:	Antisera to CRMP2 (C-terminal) were raised by repeated immunisations of goats with highly purified antigen.
Preservative Stabilisers:		0. 09%Sodium Azide (NaN3) Suggested
Dilution:	Western Blot: This product detects bands of approximately 62 and 124kDa in human Alzheimer disease brain cell lysates. Suggested
Dilution:	ELISA - 1:10000Western Blotting - 1:3000
Function:	Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance neuronal growth cone collapse and cell migration (By similarity).
Subunit:	Homotetramer and heterotetramer with CRMP1 DPYSL3 DPYSL4 or DPYSL5 (By similarity). Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4 (By similarity).
Subcellular Location:	Cytoplasm (By similarity).
Tissue Specificity:	Ubiquitous.
Ptm:	3F4 a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains specifically labels DPYSL2 when phosphorylated on Ser-518 Ser-522 and Thr-509.
Similarity:	Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. 1. Kawano. Y. et al. (2005) CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 ml

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