HISTONE H4

HISTONE H4 NCBI

HISTONE H4

Acetylated isoforms of histone H4

ELISA - 1/400Western Blotting - 1/800Immunofluorescence - 1/200R Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome an octamer composed of pairs of each of the four core histones (H2A H2B H3 and H4). The chromatin fiber is further compacted through the interaction of a linker histone H1 with the DNA between the nucleosomes to form higher order chromatin structures. This protein is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead they contain a palindromic termination element. This protein is found in a histone cluster on chromosome 1. This protein is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome an octamer composed of pairs of each of the four core histones (H2A H2B H3 and H4). The chromatin fiber is further compacted through the interaction of a linker histone H1 with the DNA between the nucleosomes to form higher order chromatin structures. This protein is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead they contain a palindromic termination element. This protein is found in a histone cluster on chromosome 1. This protein is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. 1. Turner. B. M. et al. (1989) Histone H4 acetylation in human cells. Frequency of acetylation at different sites defined by immunolabelling with site-specific antibodies. 2. Turner. B. M. et al. (1992) Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei. 3. Belyaev. N. D. et al. (1996) Differential underacetylation of histones H2A. H3 and H4 on the inactive X chromosome in human female cells.