CYTOCHROME P450 3A4

CYTOCHROME P450 3A4NCBI

CYTOCHROME P450 3A4

This product recognises human cytochrome p450 3A4 (CYP3A4). P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1 2 and 3. The xenobiotic p450\' s are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members:CYP3A CYP2D6 CYP1A2 CYP2C9/10 CYP2C19 and CYP2E1. This product is a neutralizing antibody which is a specific and potent inhibitor of CYP3A4.

Western Blotting - 1:5000 - 1:10000Functional Assays - 2-20ul Summary: This protein CYP3A4 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today including acetaminophen codeine cyclosporin A diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This protein is part of a cluster of cytochrome P450 genes on chromosome 7q21. 1. Previously another CYP3A gene CYP3A3 was thought to exist; however it is now thought that this sequence represents a transcript variant of CYP3A4. Summary: This protein CYP3A4 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today including acetaminophen codeine cyclosporin A diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This protein is part of a cluster of cytochrome P450 genes on chromosome 7q21. 1. Previously another CYP3A gene CYP3A3 was thought to exist; however it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq]. 1. Werck-Reichhart. D. and Feyereisen. R. (2000) Protein family review Cytochromes P450: a success story. 2. Ng. P. et al. (2003) Production of inhibitory polyclonal antibodies against cytochrome P450s.