SRC3

SRC3NCBI

SRC3

This product is specific for human nuclear SRC3 (steroid receptor coactivator 3) also known as NCOA3 AIB1 and p/CIP. SRC3 is a member of the steroid receptor coactivator family members which interact with nuclear receptors and enhance the transcription of target genes in a ligand-dependent manner. SRC3 has been shown to interact with several steroid receptors such as oestrogen receptor alpha and progesterone receptor. Overexpression of SRC3 has been reported in a number of cancers including breast cancer. In addition SRC3 has recently been shown to interact with IKK suggesting that SRC3 may be involved in inflammatory and immune responses mediated by NF-kappaB.

Tris-citrate/phosphate buffer pH7-8

Suggested

Contains 1 basic helix-loop-helix (bHLH) domain. Summary: The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition a polymorphic repeat region is found in the C-terminus of the encoded protein.