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ALPHA 1 ANTICHYMOTRYPSIN

ALPHA 1 ANTICHYMOTRYPSIN


Item no.	18-783-77321
Manufacturer	GENWAY
Amount	1 ml
Category	Oncology Antibodies Immunohistochemistry ELISA Primary Antibodies By Organ Testicular & Prostate Cancer
Type	Antibody
Applications	IHC, ELISA
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-481FD1
Similar products	18-783-77321
Available
Genway ID:	GWB-481FD1
Specificity:	ALPHA 1 ANTICHYMOTRYPSIN
Specificity:	ALPHA 1 ANTICHYMOTRYPSIN
Immunogen:	Human serum alpha 1 antichymotrypsin purified from plasma
Specificity Note:	This product is specific for alpha 1 antichymotrypsin (AACT). AACT is a member of the serpin superfamily of serine proteinase inhibitors. It protects the lower respiratory tract from proteolytic damage by inhibiting chymotrypsin-like proteinases and also plays a role in the acute phase response.
Preparation:	Ammonium Sulphate fractionation
Buffer Solution:	Phosphate buffered saline pH 7. 2
Preservative Stabilisers:		0. 09%Sodium Azide (NaN3) Suggested
Dilution:	Suggested
Dilution:	Immunohistology - Frozen - 1/25 - 1/100
Function:	Although its physiological function is unclear it can inhibit neutrophil cathepsin G and mast cell chymase both of which can convert angiotensin-1 to the active angiotensin-2.
Subunit:	Interacts with DNAJC1.
Subcellular Location:	Secreted.
Tissue Specificity:	Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin its concentration increases in the acute phase of inflammation or infection. Found in the myloid plaques from the hippocampus of Alzheimer\' s disease brains.
Domain:	The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
Disease:	Defects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].
Miscellaneous:	Alpha-1-antichymotrypsin can bind DNA.
Similarity:	Belongs to the serpin family. 1. Kamboh. M. I. et al. (2006) Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer\' s dise

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 ml

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Delivery expected until 8/28/2025

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