VDR

GWB-204005

7421

Peptide sequence CGNQDYKYRVSD corresponding to the internal region of VDR (NP_000367. 1).

Antisera to human VDR were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

ELISA - 1:16 000Western Blotting - 0. 3 - 1. 0ug/ml Summary: This protein is the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein. N/A 1. Cheng. H. et al. (2006) Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex.