LOX-1

LOX-1NCBI

LOX-1

Antisera to human LOX-1 were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Flow Cytometry - 1:10Immunoprecipitation - NeatWestern Blotting - 1:10 - 1/100 Summary: This protein is a receptor protein which belongs to the C-type lectin superfamily. This protein is regulated through the cyclic AMP signaling pathway. The encoded protein binds internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis risk of myocardial infarction and may modify the risk of Alzheimer\' s disease. Alternative transcript variants have been described but their full-length sequence has not been determined. Summary: This protein is a receptor protein which belongs to the C-type lectin superfamily. This protein is regulated through the cyclic AMP signaling pathway. The encoded protein binds internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis risk of myocardial infarction and may modify the risk of Alzheimer\' s disease. Alternative transcript variants have been described but their full-length sequence has not been determined. [provided by RefSeq]. 1. Chen. M. et al. (2002) LOX-1. the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. 2. Li. D. et al. (2003) LOX-1. an oxidized LDL endothelial receptor. induces CD40/CD40L signaling in human coronary artery endothelial cells. 3. Morawietz. H. et al. (1999) Angiotensin II induces LOX-1. the human endothelial receptor for oxidized low-density lipoprotein. 4. Sawamura. T. et al. (1997) An endothelial receptor for oxidized low-density lipoprotein. 5. Yoshida. H. et al. (1998) Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor.