CD156b

GWB-DC6F72

CD156b

This product detects an epitope within the C-terminus of isoform 1 of CD156b a type I transmembrane glycoprotein which belongs to the ADAM (a disintegrin and metalloprotease domain) family. CD156b is 125kD and functions as a tumour necrosis factor-alpha converting enzyme (TACE). CD156b also causes a number of inflammatory modulators to undergo ectodomain shedding including TNFR75 IL-1RII TNFR55 L-selectin and the amyloid precursor protein among others. CD156b plays a prominent role in the activation of the Notch signalling pathway. ADAM17 plays a pivotal role in several acquired tumor cell capabilities by mediating the availability of soluble transforming growth factor-alpha and establishing an autocrine signaling pathway through endogenous EGFR activation. CD156b is therefore a prospective therapeutic target in human cancer.

TRIS buffered saline pH7. 3

Western Blot: This product detects a band of approximately 125-130kDa in HeLa. Jurkat and U937 cell lysates. Suggested

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins including p75 TNF-receptor interleukin 1 receptor type II p55 TNF-receptor transforming growth factor-alpha L-selectin growth hormone receptor MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).

Interacts with MAD2L1 and MUC1.

Ubiquitously expressed. Expressed at highest levels in adult heart placenta skeletal muscle pancreas spleen thymus prostate testes ovary and small intestine and in fetal brain lung liver and kidney.

Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity).

The precursor is cleaved by a furin endopeptidase (By similarity).

Contains 1 disintegrin domain.