Phospho Stat-3 (pS727)

GWB-21FC17

A synthetic phospho-peptide corresponding to residues surrounding Ser727 of human Stat3 was used as immunogen. The antibody detects Stat3 phosphorylated on Serine 727. It does not cross-react with the phospho-serines of other Stat proteins. Predicted to c

WB: 1:2 000IHC: 1:50ICC: 1:100IP: 1:40. Stat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors as well as transcription factors (1 2). Stats are activated by tyrosine phosphorylation in response to different ligands after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3-activated transcription seems to be regulated by serine phosphorylation at Ser727 (4). 1. Simonssona M Qvarnstro ¨ ma F Nymanb J et al Low-dose hypersensitive cH2AX response and infrequent apoptosis in epidermis from radiotherapy patients Radiotherapy and Oncology 88 (2008) 388-397[Application: IHC]2. Wang GF Mao WM Zheng S MicroRNA-183 regulates Ezrin expression in lung cancer cells FEBS Letters 582 (2008) 3663-3668[Application: WB]3. Lindeman JHN Abdul-Hussien H Bockel JH et al Clinical Trial of Doxycycline for Matrix Metalloproteinase-9 Inhibition in Patients With an Abdominal Aneurysm Doxycycline Selectively Depletes Aortic Wall Neutrophils and Cytotoxic T Cells Circulation 119 (2009) 2209-2216[Application: WB]1. Heim M. H. The Jak-STAT