PI3-kinase p110 subunit delta

GWB-28DA26

A synthetic peptide of human PI3-K p110 delta was used as an immunogen.

WB: 1:500ICC: 1:250-500IP: 1:50. PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found; the a beta and the subunit (3). The delta isoform is predominantly expressed in leukocytes and has been shown to interact with p85 and GTP-bound Ras via its SH2/SH3 domain (4). 1. Jaiswal BS Janakiraman V Kljavin NM et al PI3-kinase p110 subunit delta Cancer Cell 16 (2009) 463-474[Application: WB]2. Pang H Flinn R Patsialou A et al PI3-kinase p110 subunit delta Cancer Res 69 (2009) 8868-88763. Pang H Flinn R Patsialou A et al Differential Enhancement of Breast Cancer Cell Motility and Metastasis by Helical and Kinase Domain Mutations of Class IA Phosphoinositide 3-Kinase Cancer Res 69 (2009) 8868-8876[Application: WB]1. Otsu M. Hiles I. D. Gout I. Fry M. J. Ruiz-Larrea F. Panayatou G. Thompson A. Dhand R. Hsuan J. Totty N. Smith A. D. Morgan S. J. Courtnidge S. A. Parker P. J. and Waterfield M. D. (1992) Cell 65 91-1042. Hiles I. D. Otsu M. Volinia S. Fry M. J. Gout I. Dhand R. Panayatou G. Ruiz-Larrea F. Thompson A. Totty N. F. Hsuan J. J. Courtnidge S. A. Parker P. J. and Waterfield M. D. (1991) Cell 70 419-4293. Hu P. Mondino A. Skolnik E. Y. and Schlessinger J. (1993) Mol. Cell. Biol. 13 7677-76884. Rodriguez-Viciana P. Warne P. H. Vanhaesebroeck B. Waterfield M. D. & Downward J. (1996) EMBO J. 15 2442-24515. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487