Cyclin E2

GWB-9F22DB

A synthetic peptide corresponding to a residue of human Cyclin E2 was used as an immunogen.

WB: 1:2000IHC: 1:250 - 500ICC: 1:100 - 250IP: 1:50. Cyclin E2 is a member of the cyclin E family that can associate with and activate Cdk2. Expression of cyclin E2 is essential for the control of the cell cycle at the late G1 and early S phase and this protein may regulate distinct rate-limiting pathway(s) during this phase (1). Cyclin E2 specifically interacts with Cdk inhibitors of the CIP/KIP family and activates both Cdk2 and Cdk3. Expression of the viral E6 oncoprotein in normal human fibroblasts increases levels of cyclin E2 but not cyclin E1 while expression of the E7 oncoprotein upregulates both (2). Abnormally high levels of cyclin E expression have frequently been observed in human cancers (3). 1. Caldon CE Sergio CM Schà ¼ tte J et al Estrogen Regulation of Cyclin E2 Requires Cyclin D1 but Not c-Myc Mol. Cell. Biol. 29 (2009) 4623 - 4639[Application: IP]2. Pechkovsky DV Scaffidi AK Hackett TL et al Transforming Growth Factor Î ² 1 Induces Î ± vÎ ² 3 Integrin Expression in Human Lung Fibroblasts via Î ± Î ² 3 Integrin- c-Src- and p38 MAPK-dependent Pathway J. Biol. Chem. 283 (2008) 12898 - 12908[Application: WB]1. Lauper N. et al. Oncogene 17: 26372. Zariwala M. et al. Oncogene 17: 27873. Gudas J. M. et al. Mol Cell Biol. 19: 6124. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487