Musashi1

GWB-B0A0C7

A synthetic peptide corresponding to residues on the N-terminus of human Musashi1 was used as an immunogen.

WB: 1:2000IHC: 1:50 100ICC: 1:250 500FC: 1:40IP: 1:50. Musashi1 a neural RNA-binding protein plays an important role in regulating cell differentiation in precursor cells. Recently expression of Musashi1 has been detected in human tumor tissues such as gliomas and melanomas suggesting its involvement in oncogenic development. Results suggest that Musashi1 expression may be an important factor in the development of several types of carcinoma such as human hepatoma and may be a useful molecular marker for tumor detection. (1). Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved neural RNA-binding protein Musashi1 controls neural cell fate. The protein functions in maintenance of the stem-cell state differentiation and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signaling by repressing translation of the Notch inhibitor m-Numb (2). 1. Shu HJ et al. Biochem Biophys Res Commun 293(1):150- 4 2002. 2. Okana H et al. J Cell Sci. 115(7):1355-9 2002. 3. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487