Apolipoprotein E (apo E)

GWB-F8EFBE

A synthetic peptide corresponding to residues near the C-term of human apolipoprotein E was used as an immunogen.

WB: 1:1 000 - 10 000IHC: 1:100 250ICC: 1:250 500IP: 1:100. The apolipoproteins are family of amphipathic lipoproteins that plays a crucial role in lipid metabolism. In particular apolipoprotein E (apo E) is a major component of high density lipoproteins (HDL) chylomicrons and very low-density lipoprotein (VLDL) which functions to remove excess cholesterol. Apo E mediates lipid metabolism and cholesterol homeostasis by binding to several hepatic lipoprotein receptors such as low density lipoprotein receptor (LDLR) and the LDLR-related protein (1). Apo E deficiency is linked to hyperlipoproteinemia type III; a genetic disorder characterized by elevated plasma cholesterol and triglyceride levels and accelerated coronary artery disease (2). Three major isoforms of Apo E (E2 E3 E4) has been identified with E3 being the most common in human. E4 presence has been associated to increase probability of developing late-onset form of Alzheimer disease (3). 1. Zaioua M et al Journal of Lipid Research 41:1087-1095 20002. Mahley RW and SC Rall Jr. 7th ed. McGraw-Hill New York. 1995. 3. Olarte L et al Arch Neurol. 63(11):1586-90 20064. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487