C-reactive protein (C-term)

GWB-C1BE94

A synthetic peptide corresponding to residues near the N-term of human C-reactive protein was used as immunogen.

WB: 1:1000. Human C-reactive protein (CRP) was discovered in serum of patients as a nonantibody precipitin of the C-polysaccharide from pneumococci(1). During acute infection the amounts of circulating CPR increases 100-1000 fold (2). Serum CRP values are routinely measured to detect or monitor many human diseases and minor elevations of C-reactive protein are predictive of cardiovascular events in patients with coronary heart disease (3). CRP promotes host defense is an efficient activator of the classical C cascade and shown to be opsonic (4). The opsonic and C activation activities are responsible for the nonspecific host defense activities providing protection in the preimmune stage of acute infections. Additionally IL-1 and IL-6 are known to stimulate CRP biosyntesis (5). 1. Tillet W. S. & Francis T. (1930) J. Exp. Med. 52 561-5712. Kushner I. (1982) Ann. N. Y. Acad. Sci. 389. 39-483. Ridker P. M. ; Rifai N. ; Rose L. ; Buring J. E. ; Cook N. R. : New Eng. J. Med. 347: 1557-1565 20024. Mortensen R. F. Osmand A. P. Lint T. F. & Gewurz H. (1976) J. Immunol. 117 774-7815. Kleemann R Gervois PP Verschuren L Staels B Princen HM Kooistra T. Blood. 2003 Jan 15; 101(2):545-51. Epub 2002 Aug 29. 6. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487