Cytokeratin 14

GWB-669251

A synthetic peptide corresponding to residues near the C-terminus of human Cytokeratin 14 was used as an immunogen.

WB: 1:20 000IHC: 1:100 - 250FC: 1:30IP: 1:50. Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Cytokeratin 14 (CK-14) is a 50-kDa keratin expressed in abundance in human epidermal cells (1). During anagen cell proliferation in the germinative matrix of the hair follicle gives rise to the fiber and inner root sheath. The transition from anagen to telogen is marked by downregulation of hair cortical specific keratins and the appearance of CK-14 in the epithelial sac to which the telogen hair fiber is anchored (2). A family with recessive epidermolysis bullosa simplex lacked expression of the basal cell keratin 14. The patients had severe generalized skin blistering that improved slightly with age. The basal cells of the patients did not express keratin 14 and contained no keratin intermediate filaments. The expression of keratin 5 the obligate copolymer of keratin 14 was slightly reduced (3). 1. Di Nunzio F Maruggi G Ferrari S et al cytokeratin-14 Mol Ther 16 (2008) 1977-1985[Application: IHC]2. Barbaro V Ferrari S Fasolo A et al Reconstruction of a human hemicornea through natural scaffolds compatible with the growth of corneal epithelial stem cells and stromal keratocytes Mol Vis 15 (2009) 2084-2093[Application: ICC]1. Marchuk D et al. Proc Natl Acad Sci 82(6):1609-13 19852. Bowden PE et al. J Invest Dermatol 110(2):158-64 19983. Jonkman MF et al. J Invest Dermatol 107(5):764-9 19964. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487