Acetyl CoA Carboxylase 1 (ACC1) Phos. (pS79)

GWB-BB9909

A phospho specific peptide corresponding to residues surrounding serine 79 of human ACC1 was used as an immunogen. This antibody detects ACC1 phosphorylated at serine 79.

WB: 1:5000 - 10000ICC: 1:100 - 250. Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation producing malonyl-CoA a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate CoA and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK at Ser79 and others) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues ACC1 is found in liver adipose and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4). 1. Jianqiang M et al. PNAS 100:7515-7520 20032. Girad J et al. The FASEB Journal 8:36-42 1994. 3. Wakil SJ et al. Annu Rev Biochem 52:537-5394. Abu-Elheiga L et al. Science 291: 2613-2616. 2001. 5. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487