RBL4 [KAB40]

GWB-1740A8

IgG1

Human

CC3A whole cell lysate

Nuclear

Phosphate-buffered saline pH 7. 2 containing 0. 08% Sodium Azide

Nuclear Two retinoblastoma related proteins p107 and pRb2 / p130 which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105) were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the \" \" pocket domain. \" \" Like pRb both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130 which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.

Interacts with AATF. Interacts with SUV420H1 and SUV420H2 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4 E2F5 LIN9 LIN37 LIN52 LIN54 MYBL1 MYBL2 RBL1 RBL2 RBBP4 TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9 LIN37 LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1.

During G0 and early G1 phase of the cell cycle phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.

Belongs to the retinoblastoma protein (RB) family.