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TLR4 [HTA125] (PE)

TLR4 [HTA125] (PE)

Item no.	20-272-190418
Manufacturer	GENWAY
Amount	50 TESTS
Category	Oncology Metabolism Diabetes Glucose Homeostasis Antibodies Obesity Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Clone	HTA125
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-F89C97
Similar products	20-272-190418
Available
Genway ID:	GWB-F89C97
Clone:	HTA125
Isotype:	IgG2a
Immunogen:	Ba/F3 cell line expressing human TLR4.
Antigen Species:	Human
Specificity:	This product recognises the human Toll like receptor 4 (TLR4) cell surface antigen. This antibody has been demonstrated to block activation of monocytes with LPS.
Positive Control:	Human monocytes and macrophages/whole blood.
Target:	TLR4
Conjugation:	PE Storage
Preservative:	0. 09% Sodium Azide; Constituents: 1% BSA PBS
Application Note:	FACS: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Type I membrane protein. Myeloma: Sp2/0 Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response while the related 18-wheeler is involved in antibacterial defenses. In mammals TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities have been implicated in the innate host defense to pathogens.
Function:	Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88 TIRAP and TRAF6 leading to NF-kappa-B activation cytokine secretion and the inflammatory response.
Subunit:	Belongs to the lipopolysaccharide (LPS) receptor a multi-protein complex containing at least CD14 LY96 and TLR4. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Highly expressed in placenta spleen and peripheral blood leukocytes. Detected in monocytes macrophages dendritic cells and several types of T-cells.
Domain:	The TIR domain mediates interaction with NOX4.
Ptm:	N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell surface and the LPS-response. Likewise mutants lacking two or more of the other N-glycosylation sites were deficient in interaction with LPS.
Polymorphism:	Allele TLR4*B (Gly-299 Ile-399) is associated with a blunted response to inhaled LPS.
Disease:	Genetic variation in TLR4 is associated with age-related macular degeneration type 10 (ARMD10) [MIM:611488]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
Similarity:	Belongs to the Toll-like receptor family.
Similarity:	Contains 21 LRR (leucine-rich) repeats.
Similarity:	Contains 1 TIR domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 TESTS

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Delivery expected until 10/30/2025

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