EGFR [ICR61]

ICR61

Breast carcinoma cells.

Cell Membrane and Secreted

0. 2% Sodium Azide; Constituents: PBS

Cell Membrane and Secreted EGFR is the prototype member of the type 1 receptor tyrosine kinases. EGFR is encoded by the cellular oncogene c-erbB-1. EGFR has an extracellular ligand binding domain a single transmembrane region and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. EGFR over-expression in tumors indicates poor prognosis. EGFR over-expression is observed in tumors of the head and neck brain bladder stomach breast lung endometrium cervix vulva ovary esophagus stomach and in squamous cell carcinoma.

Isoform 2/truncated isoform may act as an antagonist.

Binds RIPK1. CBL interacts with the autophosphorylated C-terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B maybe indirectly. Interacts with PELP1. Binds MUC1.

Isoform 2: Secreted.

Phosphorylation of Ser-695 is partial and occurs only if Thr-693 is phosphorylated.

Defects in EGFR are associated with lung cancer [MIM:211980].

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.