sRANKL [12A380]

GWB-F27478

IgG1

Human

Activated EL4 cells

Cell Membrane and Secreted

Affinity purified. Storage

WB: Use at a concentration of 2 - 4 µ g/ml. Detects a band of approximately 40 kDa (predicted

Cell Membrane and Secreted sRANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6 which indicated this protein may have a role in the regulation of cell apoptosis.

Homotrimer (By similarity).

Isoform 3: Cell membrane; Single-pass type II membrane protein.

Tumor necrosis factor ligand superfamily member 11 soluble form: Secreted (By similarity).

Up-regulated by T-cell receptor stimulation.

Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2) [MIM:259710]; also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero infancy or childhood and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB2 is characterized by paucity of osteoclasts suggesting a molecular defect in osteoclast development.