Ghrelin [Ghr2]

Ghr2

Synthetic peptide (Human)

Ghrelin

1. 2 mg/ml Storage

ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted

Secreted Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release from the pituitary. It has an appetite stimulating effect induces adiposity and stimulates gastric acid secretion and it is involved in growth regulation. Ghrelin is synthesized as a preprohormone then proteolytically processed to yield a 28 amino acid peptide. An interesting and unique modification is imposed on the hormone during synthesis in the form of an n octanoic acid bound to one of its amino acids. This modification is necessary for biologic activity.

Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).

Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.

Amidation of Leu-98 is essential for obestatin activity (By similarity). Mass Spectrometry: Mass=3398. 9; Mass_error=0. 3; Method=Electrospray; Range=24-51; Note=Ghrelin-28-C10 O-decanoylated form; Source=PubMed:12414809; . Mass Spectrometry: Mass=3397. 2; Mass_error=0. 5; Method=Electrospray; Range=24-51; Note=Ghrelin-28-C10:1 O-decenoylated form; Source=PubMed:12414809; . Mass Spectrometry: Mass=3371. 3; Mass_error=0. 1; Method=Electrospray; Range=24-51; Note=Ghrelin-28-C8 O-octanoylated form; Source=PubMed:12414809; . Mass Spectrometry: Mass=3243. 6; Mass_error=0. 4; Method=Electrospray; Range=24-50; Note=Ghrelin-27-C10 O-decanoylated form; Source=PubMed:12414809; . Mass Spectrometry: Mass=3214. 6; Mass_error=0. 6; Method=Electrospray; Range=24-50; Note=Ghrelin-27-C8 O-octanoylated form; Source=PubMed:12414809; .