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CD105 [MEM-226] (FITC )

CD105 [MEM-226] (FITC )

Item no.	20-272-191683
Manufacturer	GENWAY
Amount	100 TESTS
Category	Oncology Neuroscience Neuroinflammation Molecular Targets for Neuroscience Neural Development Antibodies By Cell Type Carcinoma Primary Antibodies By Organ Bone Cancer
Type	Antibody
Clone	MEM-226
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-4889A1
Similar products	20-272-191683
Available
Genway ID:	GWB-4889A1
Clone:	MEM-226
Isotype:	IgG2a
Immunogen:	Recombinant Vaccinia virus containing the human CD105 cDNA.
Antigen Species:	Human
Target:	CD105
Localization:	Cell Membrane
Conjugation:	FITC Storage
Preservative:	15mM Sodium Azide. Constituents: PBS BSA. pH 7. 4
Application Note:	FACS: 1/5. This reagent is designed for Flow Cytometry analysis of human blood cells using 20 µ l reagent / 100 µ l sample. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane CD105 or Endoglin is a Type I transmembrane protein which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
Function:	Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
Subunit:	Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1 and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Endoglin is restricted to endothelial cells in all tissues except bone marrow.
Disease:	Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia characterized by recurrent epistaxis muco-cutaneous telangiectases gastro-intestinal hemorrhage and pulmonary (PAVM) cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed there is an important clinical heterogeneity.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 TESTS

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Delivery expected until 8/28/2025

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