ORC1 [7F6/1]

7F6/1

Full length protein (Human).

HeLa cells

Nuclear.

Phosphate-buffered saline pH 7. 2 containing 1% BSA and 0. 09% sodium azide

Nuclear Myeloma: Sp2/0-Ag14 DNA replication in Saccharomyces cerevisiae requires the action of a multisubunit complex of six proteins known as the origin recognition complex (ORC). The identification of higher eukaryotic homologs of several ORC components suggests a universal role for this complex in DNA replication. ORC1 a sub-unit of the Origin Recognition Complex (ORC) is involved in the initiation of DNA replication. In human cells expression of ORC1 has been shown to be low in quiescent cells but dramatically induced upon stimulation of cell growth. In contrast expression of the HsOrc2 gene does not appear to be similarly regulated. HsORC1 a recently identified human protein related to yeast Orc1p and Cdc6p / Cdc18p may be a component of the replication initiation complex in human cells.

ORC is composed of six subunits. Interacts with CDC6 and MYST2/HBO1.

Belongs to the ORC1 family.